Scientific publications from Syn2PSy Research groups

(most relevant since 2021)

L Calderon, FD Weiss, JA Beagan, MS Oliveira, R Georgieva, YF Wang, TS Carroll, G Dharmalingam, W Gong, K Tossell, V de Paola, C Whilding, MA Ungless, AG Fisher, JE Phillips-Cremins, M Merkenschlager. Cohesin-dependence of neuronal gene expression relates to chromatin loop length. Elife (26 Apr 2022). 10.7554/eLife.76539

I Zalachoras, S Astori, M Meijer, J Grosse, O Zanoletti, IG de Suduiraut, JM Deussing, C Sandi. Opposite effects of stress on effortful motivation in high and low anxiety are mediated by CRHR1 in the VTA. Sci Adv. (25 Mar 2022). 10.1126/sciadv.abj9019

L Morató, S Astori, I Zalachoras, J Rodrigues, S Ghosal, W Huang, I Guillot de Suduiraut, J Grosse, O Zanoletti, L Cao, J Auwerx, C Sandi. eNAMPT actions through nucleus accumbens NAD+/SIRT1 link increased adiposity with sociability deficits programmed by peripuberty stress. Sci Adv. (4 Mar 2022). 10.1126/sciadv.abj9109

GL Caldeira, AS Inácio, N Beltrão, CAV Barreto, MV Rodrigues, T Rondão, R Macedo, RP Gouveia, M Edfawy, J Guedes, B Cruz, SR Louros, IS Moreira, J Peça and AL Carvalho. Aberrant hippocampal transmission and behavior in mice with a stargazin mutation linked to intellectual disability. Mol Psychiatry (7 Mar 2022). 10.1038/s41380-022-01487-w

SM Till, RDL Hickson, PC Kind. Cross-species considerations in models of neurodevelopmental disorders. Trends Neurosci. (Mar 2022). 10.1016/j.tins.2021.12.005

L Duran-Trio, F Fernandes-Pires, J Grosse, I Soro-Arnaiz, C Roux-Petronelli C, PA Binz, K De Bock, C Cudalbu, C Sandi, O Braissant. Creatine transporter-deficient rat model shows motor dysfunction, cerebellar alterations, and muscle creatine deficiency without muscle atrophy. J Inherit Metab Dis. (Mar 2022). 10.1002/jimd.12470

A De La Rossa, MH Laporte, S Astori, T Marissal, S Montessuit, P Sheshadri, E Ramos-Fernández, P Mendez, A Khani, C Quairiaux, EB Taylor, J Rutter, JM Nunes, A Carleton, MR Duchen, C Sandi, JC Martinou. Paradoxical neuronal hyperexcitability in a mouse model of mitochondrial pyruvate import deficiency. Elife (21 Feb 2022). 10.7554/eLife.72595

IL Salazar, AST Lourenço, B Manadas, I Baldeiras, C Ferreira, AC Teixeira, VM Mendes, AM Novo, R Machado, S Batista, MC Macário, M Grãos, L Sousa, MJ Saraiva, AACC Pais and CB Duarte. Posttranslational modifications of proteins are key features in the identification of CSF biomarkers of multiple sclerosis. J Neuroinflammation (8 Feb 2022). 10.1186/s12974-022-02404-2

S Ramírez, R Haddad-Tóvolli, M Radosevic, M Toledo, A Pané, D Alcolea D, V Ribas, M Milà-Guasch, M Pozo, A Obri, E Eyre, AG Gómez-Valadés, I Chivite, T Van Eeckhout, I Zalachoras, J Altirriba, C Bauder, M Imbernón, G Garrabou, C Garcia-Ruiz, R Nogueiras, D Soto, X Gasull, C Sandi, JC Brüning , J Fortea, A Jiménez, JC Fernández-Checa, M Claret. Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders. Cell Metab. (1 Feb 2022) 10.1016/j.cmet.2021.12.023

C Bowman, U Richter, CR Jones, C Agerskov, Herrik KF. Activity-State Dependent Reversal of Ketamine-Induced Resting State EEG Effects by Clozapine and Naltrexone in the Freely Moving Rat. Front Psychiatry. (27 Jan 2022). 10.3389/fpsyt.2022.737295.

K Bonnycastle, PC Kind, MA Cousin. FMRP Sustains Presynaptic Function via Control of Activity-Dependent Bulk Endocytosis. J Neurosci. (7 Jan 2022). 10.1523/JNEUROSCI.0852-21.2021

JP Brás, I Guillot de Suduiraut, O Zanoletti, S Monari, M Meijer, J Grosse, JA Barbosa, SG Santos, C Sandi, MI Almeida. Stress-induced depressive-like behavior in male rats is associated with microglial activation and inflammation dysregulation in the hippocampus in adulthood. Brain Behav Immun. (Jan 2022). 10.1016/j.bbi.2021.10.018

AL Carvalho and Dominique Fernandes. It takes two to tango: Concerted protein translation and degradation necessary for synaptic scaling. PLOS Biology (24 Nov 2021). 10.1371/journal.pbio.3001448

D Bessa-Neto, G Beliu, A Kuhlemann, V Pecoraro, S Doose, N Retailleau, N Chevrier, D Perrais, M Sauer, D Choquet. Bioorthogonal labeling of transmembrane proteins with non-canonical amino acids unveils masked epitopes in live neurons. Nat Commun. (18 Nov 2021). 10.1038/s41467-021-27025-w

C Sandi, MR Carey. COVID-19, stress, and inequities in (neuro)science. Neuron. (3 Nov 2021). 10.1016/j.neuron.2021.08.031

E Harris, H Myers, K Saxena, R Mitchell-Heggs, P Kind, S Chattarji, RGM Morris. Experiential modulation of social dominance in a SYNGAP1 rat model of Autism Spectrum Disorders. Eur J Neurosci. (2 Nov 2021). 10.1111/ejn.15500

PC Kind, A Bird. CDKL5 deficiency disorder: a pathophysiology of neural maintenance. J Clin Invest. (1 Nov 2021). 10.1172/JCI153606

I Zutshi, S Gupta, O Zanoletti, C Sandi, GL Poirier. Early life adoption shows rearing environment supersedes transgenerational effects of paternal stress on aggressive temperament in the offspring. Transl Psychiatry (16 Oct 2021)

G Fernandes, PK Mishra, MS Nawaz, PG Donlin-Asp, MM Rahman, A Hazra, S Kedia, A Kayenaat, D Songara, DJA Wyllie, EM Schuman, PC Kind, S Chattarji. Correction of amygdalar dysfunction in a rat model of fragile X syndrome. Cell Rep. (12 Oct 2021). 10.1016/j.celrep.2021.109805

HL Zieger, D Choquet. Nanoscale synapse organization and dysfunction in neurodevelopmental disorders.
Neurobiology of Disease (1 Oct 2021). 0.1016/j.nbd.2021.105453

M Bakr, D Jullié, J Krapivkina, V Paget-Blanc, L Bouit, JD Petersen, N Retailleau, C Breillat, E Herzog, D Choquet, D Perrais. The vSNAREs VAMP2 and VAMP4 control recycling and intracellular sorting of post-synaptic receptors in neuronal dendrites. Cell Reports (7 Sep 2021). 10.1016/j.celrep.2021.109678

Joana S. Ferreira, Blanka Kellermayer, AL Carvalho and L Groc. Interplay between NMDA receptor dynamics and the synaptic proteasome. European Journal of Neuroscience (17 August 2021). 10.1111/ejn.15427

H Bengani, D Grozeva, L Moyon, S Bhatia, SR Louros, J Hope, A Jackson, JG Prendergast, LJ Owen, M Naville, J Rainger, G Grimes, M Halachev, LC Murphy, O Spasic-Boskovic, V Heyningen, P Kind, CM Abbott, E Osterweil, FL Raymond, HR Crollius, DR FitzPatrick. Identification and functional modelling of plausibly causative cis-regulatory variants in a highly-selected cohort with X-linked intellectual disability. PLoS One (13 Aug 2021). 10.1371/journal.pone.0256181

SA Booker, A Sumera, PC Kind, DJA Wyllie. Contribution of NMDA Receptors to Synaptic Function in Rat Hippocampal Interneurons. eNeuro (11 Aug 2021) 10.1523/ENEURO.0552-20.2021

J Costa, S Martins, PA Ferreira, AMS Cardoso, JR Guedes, J Peça, AL Cardoso. The old guard: Age-related changes in microglia and their consequences. Mechanisms of Ageing and Development (Jul 2021). 10.1016/j.mad.2021.111512

M Mele, P De Luca, AR Santos, M Vieira, IL Salazar, PS Pinheiro, CB Duarte. GRASP1 ubiquitination regulates AMPA receptor surface expression and synaptic activity in cultured hippocampal neurons. The FASEB Journal (10 Jul 2021). 10.1096/fj.201903061RR

K Hristova, C Martinez-Gonzalez, TC Watson, NK Codadu, K Hashemi, PC Kind, MF Nolan, A Gonzalez-Sulser. Medial septal GABAergic neurons reduce seizure duration upon optogenetic closed-loop stimulation. Brain (22 Jun 2021) 10.1093/brain/awab042

M Mele, R Vieira, B Correia, P De Luca, FV Duarte, PS Pinheiro, C B Duarte. Transient incubation of cultured hippocampal neurons in the absence of magnesium induces rhythmic and synchronized epileptiform-like activity. Sci Rep (31 May 2021). 10.1038/s41598-021-90486-y

Compans, C Camus, E Kallergi, S Sposini, M Martineau, C Butler, A Kechkar, RV Klaassen, N Retailleau, TJ Sejnowski, AB Smit, J-B Sibarita, TM Bartol, D Perrais, V Nikoletopoulou, D Choquet, E Hosy. NMDAR-dependent long-term depression is associated with increased short term plasticity through autophagy mediated loss of PSD-95. B Nat Commun. (14 May 2021). 10.1038/s41467-021-23133-9

T Hosokawa, P-W Liu, Q Cai,JS Ferreira, F Levet, C Butler, J-B Sibarita, D Choquet, L Groc, E Hosy, M Zhang, Y Hayashi. CaMKII activation persistently segregates postsynaptic proteins via liquid phase separation. Nat Neurosci. (29 Apr 2021). 10.1038/s41593-021-00843-3

D Choquet, M, J-B Sibarita. Advanced imaging and labelling methods to decipher brain cell organization and function. Nat Rev Neurosci. (12 Mar 2021). 10.1038/s41583-021-00441-z

LF Ribeiro, T Catarino, M Carvalho, L Cortes, SD Santos, PO Opazo, LR Ribeiro, B Oliveiros, D Choquet, JA Esteban, J Peça and AL Carvalho. Ligand-independent activity of the ghrelin receptor modulates AMPA receptor trafficking and supports memory formation. Science Signaling (16 Feb 2021). 10.1126/scisignal.abb1953

B Tawfik, JS Martins, S Houy, C Imig, PS Pinheiro, SM Wojcik, N Brose, BH Cooper, JB Sørensen. Unraveling the Nanoscopic Organization and Function of Central Mammalian Presynapses With Super-Resolution Microscopy. eLife (22 Mar 2021). 10.7554/elife.64527

N Davis, BCMota, L Stead, EOC Palmer, L Lombardero, R Rodríguez-Puertas, V de Paola, SJ Barnes, M Sastre. Pharmacological ablation of astrocytes reduces Aβ degradation and synaptic connectivity in an ex vivo model of Alzheimer’s disease. J Neuroinflammation (17 Mar 2021) 10.1186/s12974-021-02117-y