{"id":804,"date":"2019-03-12T21:14:23","date_gmt":"2019-03-12T21:14:23","guid":{"rendered":"http:\/\/nephelae.synology.me\/wordpress\/?page_id=804"},"modified":"2020-08-21T15:21:57","modified_gmt":"2020-08-21T15:21:57","slug":"esr-project-13","status":"publish","type":"page","link":"https:\/\/syn2psy.cnc.uc.pt\/?page_id=804","title":{"rendered":"ESR Project 13"},"content":{"rendered":"\n<div class=\"wp-block-image\"><figure class=\"alignright size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/syn2psy.cnc.uc.pt\/wp-content\/uploads\/2019\/03\/Untitled-16_300x300-1.png\" alt=\"\" class=\"wp-image-806\" width=\"102\" height=\"102\" srcset=\"https:\/\/syn2psy.cnc.uc.pt\/wp-content\/uploads\/2019\/03\/Untitled-16_300x300-1.png 300w, https:\/\/syn2psy.cnc.uc.pt\/wp-content\/uploads\/2019\/03\/Untitled-16_300x300-1-150x150.png 150w\" sizes=\"auto, (max-width: 102px) 100vw, 102px\" \/><\/figure><\/div>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:17px\"><strong><a href=\"https:\/\/syn2psy.cnc.uc.pt\/?page_id=2349\">Loredana Cumpana<\/a>. Effect of corticotropin-releasing hormone (CRH) on a thalamic hub for neurodevelopmental disorders<\/strong><\/p>\n\n\n\n<p style=\"color:#14845f;font-size:19px\" class=\"has-text-color wp-block-paragraph\"><strong>Motivation<\/strong><\/p>\n\n\n\n<p class=\"has-small-font-size wp-block-paragraph\">Dysfunctions in the&nbsp;thalamocortical system are being increasingly recognized as a circuit endophenotype for neurodevelopmental disorders, such as schizophrenia (SZ) and autism spectrum disorder (ASD), and evidence suggests that the Thalamic Reticular Nucleus (TRN) is a functional hub for thalamocortical network dysfunction.<\/p>\n\n\n\n<p style=\"color:#14845f;font-size:19px\" class=\"has-text-color wp-block-paragraph\"><strong><strong>Research Challenge<\/strong><\/strong><\/p>\n\n\n\n<p class=\"has-small-font-size wp-block-paragraph\">Here we will examine the impact of stress and the anxiety-related neuropeptide CRH on the development and function of the TRN, a key element of the thalamocortical system. Endogenous corticotropin-releasing hormone (CRH) inputs to the TRN and the cell-specific localization of the corresponding CRH receptors will be identified through circuit mapping. The effects of CRH on TRN cell excitability will be tested through <em>ex vivo<\/em> electrophysiology. The impact of CRH on thalamocortical rhythms will be explored through polysomnographic recordings in freely behaving animals combined with gain-\/ loss-of-function experiments in which the TRN-projecting CRH-releasing cells will be activated\/inhibited. The behavioural concomitants will be assessed <em>in vivo<\/em>. The expression of SZ- and ASD-related genes in the TRN will be assessed after chronic exposure to CRH or early life stress exposure, and the resulting alterations in TRN cell development and function will be studied. CRH receptor-directed pharmacology will be tested to normalize the CRH-\/stress-induced phenotype.<\/p>\n\n\n\n<p class=\"has-small-font-size wp-block-paragraph\">Professor <strong>Carmen Sandi<\/strong>&#8216;s laboratory at the <strong>Brain Mind Institute (BMI-EPFL)<\/strong> investigates the impact and mechanisms whereby stress and personality affect brain function and behavior, with a focus on the social domain and, particularly, on aggression and social hierarchies.<\/p>\n\n\n\n<p style=\"color:#14845f;font-size:19px\" class=\"has-text-color wp-block-paragraph\"><strong><strong><strong><strong>Supervision and Secondments<\/strong><\/strong><\/strong><\/strong><\/p>\n\n\n\n<p class=\"has-small-font-size wp-block-paragraph\">The PhD project will be carried out in Carmen Sandi&#8217;s Laboratory of Behavioral Genetics at EPFL. The ESR will enrol in the EPFL PhD program in Neuroscience (EDNE). The project also features (extended stays) at IINS-CNRS (Laurent Groc) and ICL (Thomas Kn\u00f6pfel).<\/p>\n\n\n\n<p class=\"has-small-font-size wp-block-paragraph\"><strong>Supervisors<\/strong>: Carmen Sandi (carmen.sandi@epfl.ch), Simone Astori (simone.astori@epfl.ch)<\/p>\n\n\n\n<p class=\"has-small-font-size wp-block-paragraph\"><strong>Host Location<\/strong>: Brain Mind Institute (BMI), EPFL, Lausanne, Switzerland.<\/p>\n\n\n\n<pre class=\"wp-block-preformatted\"><a href=\"https:\/\/syn2psy.cnc.uc.pt\/research-projects\/\">&lt; return to list of projects <\/a><\/pre>\n","protected":false},"excerpt":{"rendered":"<p>Loredana Cumpana. Effect of corticotropin-releasing hormone (CRH) on a thalamic hub for neurodevelopmental disorders Motivation Dysfunctions in the&nbsp;thalamocortical system are being increasingly recognized as a circuit endophenotype for neurodevelopmental disorders, such as schizophrenia (SZ) and autism spectrum disorder (ASD), and evidence suggests that the Thalamic Reticular Nucleus (TRN) is a functional hub for thalamocortical network [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-804","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ESR Project 13 -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/syn2psy.cnc.uc.pt\/?page_id=804\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ESR Project 13 -\" \/>\n<meta property=\"og:description\" content=\"Loredana Cumpana. Effect of corticotropin-releasing hormone (CRH) on a thalamic hub for neurodevelopmental disorders Motivation Dysfunctions in the&nbsp;thalamocortical system are being increasingly recognized as a circuit endophenotype for neurodevelopmental disorders, such as schizophrenia (SZ) and autism spectrum disorder (ASD), and evidence suggests that the Thalamic Reticular Nucleus (TRN) is a functional hub for thalamocortical network [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/syn2psy.cnc.uc.pt\/?page_id=804\" \/>\n<meta property=\"article:modified_time\" content=\"2020-08-21T15:21:57+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/syn2psy.cnc.uc.pt\/wp-content\/uploads\/2019\/03\/Untitled-16_300x300-1.png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/?page_id=804\",\"url\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/?page_id=804\",\"name\":\"ESR Project 13 -\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/?page_id=804#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/?page_id=804#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/wp-content\\\/uploads\\\/2019\\\/03\\\/Untitled-16_300x300-1.png\",\"datePublished\":\"2019-03-12T21:14:23+00:00\",\"dateModified\":\"2020-08-21T15:21:57+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/?page_id=804#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/?page_id=804\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/?page_id=804#primaryimage\",\"url\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/wp-content\\\/uploads\\\/2019\\\/03\\\/Untitled-16_300x300-1.png\",\"contentUrl\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/wp-content\\\/uploads\\\/2019\\\/03\\\/Untitled-16_300x300-1.png\",\"width\":300,\"height\":300},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/?page_id=804#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"ESR Project 13\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/#website\",\"url\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/\",\"name\":\"\",\"description\":\"Synaptic Dysfunction in Neuropsychiatric Disorders\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"ESR Project 13 -","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/syn2psy.cnc.uc.pt\/?page_id=804","og_locale":"en_US","og_type":"article","og_title":"ESR Project 13 -","og_description":"Loredana Cumpana. Effect of corticotropin-releasing hormone (CRH) on a thalamic hub for neurodevelopmental disorders Motivation Dysfunctions in the&nbsp;thalamocortical system are being increasingly recognized as a circuit endophenotype for neurodevelopmental disorders, such as schizophrenia (SZ) and autism spectrum disorder (ASD), and evidence suggests that the Thalamic Reticular Nucleus (TRN) is a functional hub for thalamocortical network [&hellip;]","og_url":"https:\/\/syn2psy.cnc.uc.pt\/?page_id=804","article_modified_time":"2020-08-21T15:21:57+00:00","og_image":[{"url":"https:\/\/syn2psy.cnc.uc.pt\/wp-content\/uploads\/2019\/03\/Untitled-16_300x300-1.png","type":"","width":"","height":""}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/syn2psy.cnc.uc.pt\/?page_id=804","url":"https:\/\/syn2psy.cnc.uc.pt\/?page_id=804","name":"ESR Project 13 -","isPartOf":{"@id":"https:\/\/syn2psy.cnc.uc.pt\/#website"},"primaryImageOfPage":{"@id":"https:\/\/syn2psy.cnc.uc.pt\/?page_id=804#primaryimage"},"image":{"@id":"https:\/\/syn2psy.cnc.uc.pt\/?page_id=804#primaryimage"},"thumbnailUrl":"https:\/\/syn2psy.cnc.uc.pt\/wp-content\/uploads\/2019\/03\/Untitled-16_300x300-1.png","datePublished":"2019-03-12T21:14:23+00:00","dateModified":"2020-08-21T15:21:57+00:00","breadcrumb":{"@id":"https:\/\/syn2psy.cnc.uc.pt\/?page_id=804#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/syn2psy.cnc.uc.pt\/?page_id=804"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/syn2psy.cnc.uc.pt\/?page_id=804#primaryimage","url":"https:\/\/syn2psy.cnc.uc.pt\/wp-content\/uploads\/2019\/03\/Untitled-16_300x300-1.png","contentUrl":"https:\/\/syn2psy.cnc.uc.pt\/wp-content\/uploads\/2019\/03\/Untitled-16_300x300-1.png","width":300,"height":300},{"@type":"BreadcrumbList","@id":"https:\/\/syn2psy.cnc.uc.pt\/?page_id=804#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/syn2psy.cnc.uc.pt\/"},{"@type":"ListItem","position":2,"name":"ESR Project 13"}]},{"@type":"WebSite","@id":"https:\/\/syn2psy.cnc.uc.pt\/#website","url":"https:\/\/syn2psy.cnc.uc.pt\/","name":"","description":"Synaptic Dysfunction in Neuropsychiatric Disorders","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/syn2psy.cnc.uc.pt\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/syn2psy.cnc.uc.pt\/index.php?rest_route=\/wp\/v2\/pages\/804","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/syn2psy.cnc.uc.pt\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/syn2psy.cnc.uc.pt\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/syn2psy.cnc.uc.pt\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/syn2psy.cnc.uc.pt\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=804"}],"version-history":[{"count":3,"href":"https:\/\/syn2psy.cnc.uc.pt\/index.php?rest_route=\/wp\/v2\/pages\/804\/revisions"}],"predecessor-version":[{"id":4596,"href":"https:\/\/syn2psy.cnc.uc.pt\/index.php?rest_route=\/wp\/v2\/pages\/804\/revisions\/4596"}],"wp:attachment":[{"href":"https:\/\/syn2psy.cnc.uc.pt\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=804"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}