{"id":450,"date":"2019-03-09T13:33:03","date_gmt":"2019-03-09T13:33:03","guid":{"rendered":"http:\/\/nephelae.synology.me\/wordpress\/?page_id=450"},"modified":"2021-04-21T11:19:39","modified_gmt":"2021-04-21T11:19:39","slug":"esr-project-4","status":"publish","type":"page","link":"https:\/\/syn2psy.cnc.uc.pt\/?page_id=450","title":{"rendered":"ESR Project 4"},"content":{"rendered":"\n<div class=\"wp-block-image\"><figure class=\"alignright size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/syn2psy.cnc.uc.pt\/wp-content\/uploads\/2019\/03\/Untitled-7_300x300-1.png\" alt=\"\" class=\"wp-image-451\" width=\"117\" height=\"117\" srcset=\"https:\/\/syn2psy.cnc.uc.pt\/wp-content\/uploads\/2019\/03\/Untitled-7_300x300-1.png 300w, https:\/\/syn2psy.cnc.uc.pt\/wp-content\/uploads\/2019\/03\/Untitled-7_300x300-1-150x150.png 150w\" sizes=\"auto, (max-width: 117px) 100vw, 117px\" \/><\/figure><\/div>\n\n\n\n<p style=\"font-size:17px\" class=\"has-text-align-left wp-block-paragraph\"><strong><a href=\"https:\/\/syn2psy.cnc.uc.pt\/?page_id=4915\" target=\"_blank\" rel=\"noreferrer noopener\">Veronica Villeri.<\/a><\/strong> <strong>Linking autism related mutations in Shank3 over synaptic, network and behaviour defects<\/strong><\/p>\n\n\n\n<p style=\"color:#14845f;font-size:19px\" class=\"has-text-color wp-block-paragraph\"><strong><strong>Motivation<\/strong><\/strong><\/p>\n\n\n\n<p class=\"has-small-font-size wp-block-paragraph\">Alterations in glutamatergic synaptic transmission are a prominent feature of numerous forms of autism spectrum disorders (ASD). In particular, mutations in synaptic protein genes such as Shank3 and others have been identified as risk factors for ASD. Shank3 has been identified as a major synaptic organizer, however, surprisingly little is known yet on the mechanistic links between the molecular impact of Shank3 mutations on synapse organization and synaptic function.<\/p>\n\n\n\n<p style=\"color:#14845f;font-size:19px\" class=\"has-text-color wp-block-paragraph\"><strong>Research Challenge<\/strong><\/p>\n\n\n\n<p class=\"has-small-font-size wp-block-paragraph\">To gain insightful knowledge about those mechanistic links, we will perform a nanoscale dynamic analysis of glutamatergic synapse organization in hippocampal neurons in primary culture and organotypic slices, in various models of Shank3 related ASD. We will correlate these studies to analysis of synaptic function to propose a multi-scale link between the nanoscale synapse disorganization to synapse function and circuit properties in models of ASD.<\/p>\n\n\n\n<p class=\"has-small-font-size wp-block-paragraph\">The group of <strong>Dr. Daniel Choquet<\/strong> at the <strong>Interdisciplinary Institute for Neuroscience (IINS), University of Bordeaux&nbsp;<\/strong>has a unique joint expertise on high-resolution imaging of synapse organization, analysis of synapse function and circuit properties. Extensive state of the art facilities for advanced microscopy are available at both IINS and the University of Bordeaux.<\/p>\n\n\n\n<p style=\"color:#14845f;font-size:19px\" class=\"has-text-color wp-block-paragraph\"><strong>Supervision and Secondments<\/strong><\/p>\n\n\n\n<p class=\"has-small-font-size wp-block-paragraph\">The PhD project will be carried out in the Dynamic organization &amp; Function of Synapses research group at IINS headed by Daniel Choquet. The ESR will enrol in the Life &amp; Health Science Doctorate School of the University of Bordeaux. The project also features secondments (extended stays) at CNC (Ana Lu\u00edsa Carvalho) and Eurotrials (now CTI; Ana Cl\u00e1udia Patac\u00e3o).<\/p>\n\n\n\n<p class=\"has-small-font-size wp-block-paragraph\"><strong>Supervisors<\/strong>: Daniel Choquet (daniel.choquet@u-bordeaux.fr) and  Eric Hosy (eric.hosy@u-bordeaux.fr).<\/p>\n\n\n\n<p class=\"has-small-font-size wp-block-paragraph\"><strong>Host Location<\/strong>: Interdisciplinary Institute for Neuroscience (IINS) &#8211; CNRS, Bordeaux University, Bordeaux, France.<\/p>\n\n\n\n<pre class=\"wp-block-preformatted\"><a href=\"https:\/\/syn2psy.cnc.uc.pt\/research-projects\/\">&lt; return to list of projects <\/a><\/pre>\n","protected":false},"excerpt":{"rendered":"<p>Veronica Villeri. Linking autism related mutations in Shank3 over synaptic, network and behaviour defects Motivation Alterations in glutamatergic synaptic transmission are a prominent feature of numerous forms of autism spectrum disorders (ASD). In particular, mutations in synaptic protein genes such as Shank3 and others have been identified as risk factors for ASD. Shank3 has been [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-450","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ESR Project 4 -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/syn2psy.cnc.uc.pt\/?page_id=450\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ESR Project 4 -\" \/>\n<meta property=\"og:description\" content=\"Veronica Villeri. Linking autism related mutations in Shank3 over synaptic, network and behaviour defects Motivation Alterations in glutamatergic synaptic transmission are a prominent feature of numerous forms of autism spectrum disorders (ASD). In particular, mutations in synaptic protein genes such as Shank3 and others have been identified as risk factors for ASD. Shank3 has been [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/syn2psy.cnc.uc.pt\/?page_id=450\" \/>\n<meta property=\"article:modified_time\" content=\"2021-04-21T11:19:39+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/syn2psy.cnc.uc.pt\/wp-content\/uploads\/2019\/03\/Untitled-7_300x300-1.png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/?page_id=450\",\"url\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/?page_id=450\",\"name\":\"ESR Project 4 -\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/?page_id=450#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/?page_id=450#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/wp-content\\\/uploads\\\/2019\\\/03\\\/Untitled-7_300x300-1.png\",\"datePublished\":\"2019-03-09T13:33:03+00:00\",\"dateModified\":\"2021-04-21T11:19:39+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/?page_id=450#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/?page_id=450\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/?page_id=450#primaryimage\",\"url\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/wp-content\\\/uploads\\\/2019\\\/03\\\/Untitled-7_300x300-1.png\",\"contentUrl\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/wp-content\\\/uploads\\\/2019\\\/03\\\/Untitled-7_300x300-1.png\",\"width\":300,\"height\":300},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/?page_id=450#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"ESR Project 4\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/#website\",\"url\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/\",\"name\":\"\",\"description\":\"Synaptic Dysfunction in Neuropsychiatric Disorders\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"ESR Project 4 -","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/syn2psy.cnc.uc.pt\/?page_id=450","og_locale":"en_US","og_type":"article","og_title":"ESR Project 4 -","og_description":"Veronica Villeri. Linking autism related mutations in Shank3 over synaptic, network and behaviour defects Motivation Alterations in glutamatergic synaptic transmission are a prominent feature of numerous forms of autism spectrum disorders (ASD). In particular, mutations in synaptic protein genes such as Shank3 and others have been identified as risk factors for ASD. 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