{"id":277,"date":"2019-02-27T18:06:20","date_gmt":"2019-02-27T18:06:20","guid":{"rendered":"http:\/\/nephelae.synology.me\/wordpress\/?page_id=277"},"modified":"2020-08-21T15:14:02","modified_gmt":"2020-08-21T15:14:02","slug":"esr-project-3","status":"publish","type":"page","link":"https:\/\/syn2psy.cnc.uc.pt\/?page_id=277","title":{"rendered":"ESR Project 3"},"content":{"rendered":"\n<div class=\"wp-block-image\"><figure class=\"alignright size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/syn2psy.cnc.uc.pt\/wp-content\/uploads\/2019\/03\/Untitled-1_300x300-1.png\" alt=\"\" class=\"wp-image-395\" width=\"119\" height=\"119\" srcset=\"https:\/\/syn2psy.cnc.uc.pt\/wp-content\/uploads\/2019\/03\/Untitled-1_300x300-1.png 300w, https:\/\/syn2psy.cnc.uc.pt\/wp-content\/uploads\/2019\/03\/Untitled-1_300x300-1-150x150.png 150w\" sizes=\"auto, (max-width: 119px) 100vw, 119px\" \/><\/figure><\/div>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:17px\"><strong><a href=\"https:\/\/syn2psy.cnc.uc.pt\/?page_id=2299\">Giuseppe Cammarata<\/a>. Production and testing of human-derived neurons and brain organoids: advanced model probing in neurodevelopmental disorders<\/strong><\/p>\n\n\n\n<p style=\"color:#14845f;font-size:19px\" class=\"has-text-color wp-block-paragraph\"><strong>Motivation<\/strong><\/p>\n\n\n\n<p class=\"has-small-font-size wp-block-paragraph\">Autism and associated neurodevelopmental disabilities are chronic disorders that afflict 1 in 68 children. Not only there is no cure for these conditions but there is also an overall lack of knowledge regarding the precise neurobiological underpinnings leading to synaptic and cellular alterations in human tissue. This project aims to create patient-derived neurons to be used in the understanding of the fundamental characteristics of neurodevelopmental disorders and to identify the neurobiological changes caused by mutations present in autism patients.<\/p>\n\n\n\n<p style=\"color:#14845f;font-size:19px\" class=\"has-text-color wp-block-paragraph\"><strong>Research Challenge<\/strong><\/p>\n\n\n\n<p class=\"has-small-font-size wp-block-paragraph\">To better understand these disorders, directly accessing neural cells to probe cellular and circuit dysfunctions is both critical and challenging. Current strategies suffer from drawbacks that include heterogeneity in reprogrammed induced pluripotent stem cells and the limited access to biopsies or post-mortem brain samples. Importantly, however, recent evidences have shown that neuronal populations can be differentiated from specific postnatal niches. Dental stem cells are a particularly relevant population since they derive from the neural crest and have been shown to readily differentiate into neurons. As such, there is great potential for the application of dental stem cells in the development of human culture models and cerebral organoids that can provide a breakthrough in understanding disease mechanism.<\/p>\n\n\n\n<p class=\"has-small-font-size wp-block-paragraph\">Brain organoids from dental stem cells offer considerable potential impact as biomedical and biotechnological platform with potential for translational research with personalized medical applications. The usage of dental derived neurons displays potential to dampen the need for animal studies, reduce and contain costs associated with drug development and may provide personalized testing devices with minimally invasive strategies.<\/p>\n\n\n\n<p class=\"has-small-font-size wp-block-paragraph\">The group led by <strong>Dr. Jo\u00e3o Pe\u00e7a<\/strong> at the<strong> Center for Neuroscience and Cell biology (CNC)<\/strong>, University of Coimbra is focused on understanding neuropsychiatric disorders while dissecting the neuronal circuits controlling behaviors,&nbsp;using a combination of molecular genetics, optogenetics and electrophysiological approaches. It also has proven expertise in the development of novel, genetically engineered mouse models.<\/p>\n\n\n\n<p style=\"color:#14845f;font-size:19px\" class=\"has-text-color wp-block-paragraph\"><strong>Supervision and Secondments<\/strong><\/p>\n\n\n\n<p class=\"has-small-font-size wp-block-paragraph\"><strong>Supervision and Secondments<br><\/strong>The PhD project will be carried out in the Neuronal Circuits and Behavior research group at CNC headed by Jo\u00e3o Pe\u00e7a. The ESR will enrol in the Doctoral Programme in Experimental Biology and Biomedicine (PDBEB) coordinated by CNC. The project also features secondments (extended stays) at CIP-UEDIN (Peter Kind\/Emily Osterweil), Lundbeck (Kjartan Herrik) and CHUC (Guiomar Oliveira).<\/p>\n\n\n\n<p class=\"has-small-font-size wp-block-paragraph\"><strong>Supervisor<\/strong>: Jo\u00e3o Pe\u00e7a (jpeca@cnc.uc.pt)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Host Location<\/strong>: Center for Neuroscience and Cell biology (CNC), University of Coimbra, Coimbra, Portugal.<\/p>\n\n\n\n<pre class=\"wp-block-preformatted\"><a href=\"https:\/\/syn2psy.cnc.uc.pt\/research-projects\/\">&lt; return to list of projects <\/a><\/pre>\n","protected":false},"excerpt":{"rendered":"<p>Giuseppe Cammarata. Production and testing of human-derived neurons and brain organoids: advanced model probing in neurodevelopmental disorders Motivation Autism and associated neurodevelopmental disabilities are chronic disorders that afflict 1 in 68 children. Not only there is no cure for these conditions but there is also an overall lack of knowledge regarding the precise neurobiological underpinnings [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-277","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ESR Project 3 -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/syn2psy.cnc.uc.pt\/?page_id=277\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ESR Project 3 -\" \/>\n<meta property=\"og:description\" content=\"Giuseppe Cammarata. Production and testing of human-derived neurons and brain organoids: advanced model probing in neurodevelopmental disorders Motivation Autism and associated neurodevelopmental disabilities are chronic disorders that afflict 1 in 68 children. Not only there is no cure for these conditions but there is also an overall lack of knowledge regarding the precise neurobiological underpinnings [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/syn2psy.cnc.uc.pt\/?page_id=277\" \/>\n<meta property=\"article:modified_time\" content=\"2020-08-21T15:14:02+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/syn2psy.cnc.uc.pt\/wp-content\/uploads\/2019\/03\/Untitled-1_300x300-1.png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/?page_id=277\",\"url\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/?page_id=277\",\"name\":\"ESR Project 3 -\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/?page_id=277#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/?page_id=277#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/wp-content\\\/uploads\\\/2019\\\/03\\\/Untitled-1_300x300-1.png\",\"datePublished\":\"2019-02-27T18:06:20+00:00\",\"dateModified\":\"2020-08-21T15:14:02+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/?page_id=277#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/?page_id=277\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/?page_id=277#primaryimage\",\"url\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/wp-content\\\/uploads\\\/2019\\\/03\\\/Untitled-1_300x300-1.png\",\"contentUrl\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/wp-content\\\/uploads\\\/2019\\\/03\\\/Untitled-1_300x300-1.png\",\"width\":300,\"height\":300},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/?page_id=277#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"ESR Project 3\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/#website\",\"url\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/\",\"name\":\"\",\"description\":\"Synaptic Dysfunction in Neuropsychiatric Disorders\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/syn2psy.cnc.uc.pt\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"ESR Project 3 -","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/syn2psy.cnc.uc.pt\/?page_id=277","og_locale":"en_US","og_type":"article","og_title":"ESR Project 3 -","og_description":"Giuseppe Cammarata. Production and testing of human-derived neurons and brain organoids: advanced model probing in neurodevelopmental disorders Motivation Autism and associated neurodevelopmental disabilities are chronic disorders that afflict 1 in 68 children. Not only there is no cure for these conditions but there is also an overall lack of knowledge regarding the precise neurobiological underpinnings [&hellip;]","og_url":"https:\/\/syn2psy.cnc.uc.pt\/?page_id=277","article_modified_time":"2020-08-21T15:14:02+00:00","og_image":[{"url":"https:\/\/syn2psy.cnc.uc.pt\/wp-content\/uploads\/2019\/03\/Untitled-1_300x300-1.png","type":"","width":"","height":""}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/syn2psy.cnc.uc.pt\/?page_id=277","url":"https:\/\/syn2psy.cnc.uc.pt\/?page_id=277","name":"ESR Project 3 -","isPartOf":{"@id":"https:\/\/syn2psy.cnc.uc.pt\/#website"},"primaryImageOfPage":{"@id":"https:\/\/syn2psy.cnc.uc.pt\/?page_id=277#primaryimage"},"image":{"@id":"https:\/\/syn2psy.cnc.uc.pt\/?page_id=277#primaryimage"},"thumbnailUrl":"https:\/\/syn2psy.cnc.uc.pt\/wp-content\/uploads\/2019\/03\/Untitled-1_300x300-1.png","datePublished":"2019-02-27T18:06:20+00:00","dateModified":"2020-08-21T15:14:02+00:00","breadcrumb":{"@id":"https:\/\/syn2psy.cnc.uc.pt\/?page_id=277#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/syn2psy.cnc.uc.pt\/?page_id=277"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/syn2psy.cnc.uc.pt\/?page_id=277#primaryimage","url":"https:\/\/syn2psy.cnc.uc.pt\/wp-content\/uploads\/2019\/03\/Untitled-1_300x300-1.png","contentUrl":"https:\/\/syn2psy.cnc.uc.pt\/wp-content\/uploads\/2019\/03\/Untitled-1_300x300-1.png","width":300,"height":300},{"@type":"BreadcrumbList","@id":"https:\/\/syn2psy.cnc.uc.pt\/?page_id=277#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/syn2psy.cnc.uc.pt\/"},{"@type":"ListItem","position":2,"name":"ESR Project 3"}]},{"@type":"WebSite","@id":"https:\/\/syn2psy.cnc.uc.pt\/#website","url":"https:\/\/syn2psy.cnc.uc.pt\/","name":"","description":"Synaptic Dysfunction in Neuropsychiatric Disorders","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/syn2psy.cnc.uc.pt\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/syn2psy.cnc.uc.pt\/index.php?rest_route=\/wp\/v2\/pages\/277","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/syn2psy.cnc.uc.pt\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/syn2psy.cnc.uc.pt\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/syn2psy.cnc.uc.pt\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/syn2psy.cnc.uc.pt\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=277"}],"version-history":[{"count":5,"href":"https:\/\/syn2psy.cnc.uc.pt\/index.php?rest_route=\/wp\/v2\/pages\/277\/revisions"}],"predecessor-version":[{"id":4590,"href":"https:\/\/syn2psy.cnc.uc.pt\/index.php?rest_route=\/wp\/v2\/pages\/277\/revisions\/4590"}],"wp:attachment":[{"href":"https:\/\/syn2psy.cnc.uc.pt\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=277"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}